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Principal Scientist- Integrated Drug Discovery

Yashraj Biotechnology Limited · yashraj.com
Navi MumbaiLead / Manager
Apply on Yashraj Biotechnology Limited’s site

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The job in short

Integrated drug discovery research.

Details

Found
26 d ago · posted 2026-07-29
Location as listed
Navi Mumbai, MH, India
Role
Research Scientist
Source
The company’s own careers site

Full description

• To own YBL Vision, Values and Mission. • Reprogramming somatic cells to establish disease and healthy and disease iPSC lines, ensuring reproducibility and quality compliance throughout the process. • Differentiating iPSC lines to target derivatives (e.g., cardiac, neural, skin cell types) using lineage-specific protocols • Developing and validating NAM models which are Fit for Purpose and Context of Use (CoU). • End-to-end characterization of differentiated cells including lineage marker expression by immunofluorescence, flow cytometry, and RNA/protein-based assays. • Development and validation of CIVMs– Complex in vitro models and validation e.g. organoid, organ on chip. • Knock in knock out studies using CRISPR technology. • Documentation and maintenance of detailed records for all characterization assays to ensure traceability and regulatory compliance. • Drive the QMS process as per the ISO 9001 and 13485 compliance. • Set scientific vision and drive strategic research direction for iPSC disease modeling, differentiation technologies, and translational applications. • Lead and mentor cross-functional teams in designing, optimizing, and scaling iPSC manufacturing and differentiation processes using cutting-edge techniques. • Oversee process development from early-stage research to non-cGMP-ready manufacturing, ensuring scalability, compliance, and technology transfer. • Guide project portfolio prioritization, establish milestones, and proactively manage timelines, budgets, and resources for high-impact internal and external programs • Function as a key scientific reference, providing expert advice, troubleshooting, and decision-making support for junior and senior scientists across multiple active projects. • Represent scientific programs at regulatory meetings, conferences, and strategic partner engagements, shaping industry standards and responding to agency inquiries. • Champion innovation in assay development, process engineering, and automation for iPSC platforms, with a focus on next-generation manufacturing solutions. • Take accountability for global technical alignment, troubleshooting complex scientific and operational challenges across company sites or partner collaborations. • Foster a culture of continuous improvement and high data integrity, driving quality control, safety standards, and compliance with regulatory guidelines. • Responsible for ALCOA+++ and GMP compliance practices.

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