2025-2030 Focus Building on our previous documents and standards, particularly Chapter <11>, which already introduced digital reference standard concept. The goal is to explore how digital reference standards can serve as alternatives to physical reference standards, aligning with Chapter <11> while leveraging prior work on the broader scientific discussions within USP. 2025-2030 Key Issues In recent years, the global scientific and regulatory communities have accelerated their transition toward digital transformation to enhance data integrity, reproducibility, and analytical efficiency. The USP, as a global leader in setting public standards, has recognized the growing need to complement its traditional physical Reference Standards (RS) with Digital Reference Standards (dRS) that provide machine-readable, verifiable, and interoperable analytical data. Following the published chapter <11>, a working team is needed to develop stimuli article and new chapter, including (1) Establishing Equivalence between Digital and Physical Reference Standards; (2) Exploring Specific Digital Reference Standard Modalities; and (3) Developing Practical Guidelines. This Subcommittee will also communicate with USP’s Emerging Standards Team closely. Required Expertise NMR, IR, Raman, spectroscopy, quantum mechanical spectral analysis, digital data applications, spectral library