Scientist I Hourly Rate: $52 - $56/hr with medical benefits available at a cost Contract Length: 6-month initial contract with possibility of extension Location: 100% onsite out of South San Francisco Work Schedule: Monday – Friday standard lab hours Orion Project Services has teamed up with a market leading pharmaceutical company on an exciting contract opportunity out of South San Francisco. The Biologics CMC Development team has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure. This Scientist I role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs. Responsibilities include: • Scale-up protein purification processes, including Affinity/IEX/HIC/MM chromatography, nanofiltration, depth filtration and ultrafiltration/diafiltration • Large scale buffer preparation to support scale-up processes • Operate, troubleshoot, and maintain pilot-scale bioprocess equipment such as depth filtration systems, chromatography skids, virus filtration systems, TFF skids, mixers, tanks, pumps, and single-use assemblies • Perform pre-run readiness activities, including equipment setup, column packing/qualification, buffer/media verification, and raw material staging • Support incoming transfer processes to scale-up lab to support GLP toxicology study material production and outgoing transfer processes to GMP manufacturing site for clinical material production • Work efficiently, collaboratively, and cross-functionally toward project timelines and goals • Author standard operating procedures (SOPs), technical reports and maintain well-documented records in an electronic lab notebook (ELN) • Author and deliver technical presentations Qualifications Basic: • Bachelor’s Degree or equivalent education and typically 5 years of experience and MS or equivalent education and typically 2 years of experience • Must have CMC protein purification development experience with standard bioprocess unit operations such as chromatography separations (resin/membrane: affinity, CEX, AEX, HIC, MM) and filtration operations (depth filtration, virus filtration, sterile filtration, TFF) • Must have excellent attention to detail and ability to keep detailed written records • Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions • Demonstrated ability to learn, understand and master new experimental techniques • Able to work collaboratively within and outside of the group • Able to author technical reports and presentations • Has understanding of biochemistry and bioprocess engineering concepts • Has strong planning and analytical skills • Experience with AKTA chromatographic instruments (such as AKTA Ready, AKTA process, AKTA Avant, AKTA Purifier, AKTA Pure or similar), TFF skids (such as Sartoflow 1000 or similar) • Demonstrated scientific writing skills and strong verbal communication skills including scientific data presentations • Has proficiency with Microsoft Office software, ability to learn new software applications Preferred: • Has hands on experience with executing antibody or antibody-like molecule purification techniques including resin chromatography (affinity, CEX, AEX, MMC), depth filtration, virus filtration, membrane chromatography, and TFF operations, preferably at pilot or GMP scale • Has hands on experience with unit operation development including cell culture harvest, affinity chromatography, polishing chromatography, virus filtration and ultrafiltration/diafiltration. • Understanding of analytical techniques, such as HPLC, LAL, and ELISA • Has hands on experience with high-throughput technologies and automation People are our business worldwide Orion Group was founded in 1987 and is now one of the largest, independent, international recruitment companies. We have a network of 200 employees working from 24 offices, delivering a range of services – Talent Acquisition, Recruitment Outsourcing Services, Retained Search, Global Workforce Solutions, Completions & Commissioning and Materials Management – across 68 countries. As a global leader in workforce solutions, we recruit personnel across the Engineering & Technical, Office & Commercial, Scientific and Skilled Trades disciplines, for sectors including Oil & Gas, Life Science, Power & Utilities, Constructions & Infrastructure, Manufacturing and Renewables.