Senior Downstream Equipment Engineer
Zachary Piper · zacharypiper.com
CarySenior7+ yrs
The job in short
Downstream equipment engineering.
Insurance
Details
- Found
- 6 d ago · posted 2026-09-09
- Location as listed
- Cary, North Carolina
- Role
- Engineer (other)
- Source
- The company’s own careers site
Full description
Downstream Equipment Engineer
We are seeking a Downstream Process Engineer to support the startup and commissioning of a new commercial-scale biopharmaceutical manufacturing facility. This role will provide technical leadership for downstream purification startup efforts, supporting equipment readiness, process validation, technology transfer, and operational excellence.
Key Responsibilities
• Support qualification, and startup of downstream processing equipment and systems.
• Lead troubleshooting and optimization of chromatography skids and columns.
• Partner with Manufacturing, MSAT, Validation, Quality, and Engineering teams to ensure successful process transfer and commercial readiness.
• Provide on-floor technical support/troubleshooting support during engineering, validation, and commercial manufacturing campaigns.
• Author and review SOPs, batch records, protocols, and technical reports.
Qualifications
• Bachelor's degree in Chemical Engineering, Biochemical Engineering, Biotechnology, or related field.
• 7+ years of downstream bioprocessing experience in a GMP manufacturing environment.
• Experience with commercial-scale chromatography, filtration, and purification processes.
• Experience supporting facility startup, commissioning, qualification, or process validation activities is highly desirable.
• Strong troubleshooting, communication, and cross-functional collaboration skills.
W2 Compensation:
$175,000 - $190,000 with PTO, Paid Holidays and company subsidized medical, dental, and vision insurance.
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