Piper Companies is supporting recruiting efforts for one of the world's largest clinical research organizations seeking a Principal IT Project Manager who will work fully remote in EST hours. The ideal Principal IT Project Manager will lead large-scale technology initiatives, partnering with business and technical teams to ensure projects are delivered on time, within budget, and aligned with organizational goals in a highly regulated environment. Responsibilities of the Principal IT Project Manager: • Lead multiple complex IT projects from planning through implementation and post-launch support. • Build and manage project plans, timelines, budgets, and resource allocations. • Coordinate cross-functional teams including Product, Engineering, Infrastructure, Security, and Operations. • Provide regular project updates, status reports, and recommendations to senior leadership. • Facilitate governance meetings, steering committees, and stakeholder reviews. • Identify project risks, dependencies, and issues, developing mitigation and recovery plans as needed. • Ensure project documentation, approvals, and deliverables are maintained in accordance with company standards. • Manage project scope, change requests, and competing priorities while maintaining delivery commitments. • Support portfolio planning efforts by helping prioritize initiatives and align resources. Qualifications of the Principal IT Project Manager: • 8+ years of experience managing enterprise-level IT projects or programs. • Must be eligible to work in the United States and obtain and maintain an Active U.S. Government Secret Clearance. • Proven success delivering large, complex technology initiatives involving multiple teams and stakeholders. • Strong knowledge of Agile, Waterfall, and hybrid project management methodologies. • Experience leading projects in regulated industries such as life sciences, healthcare, pharmaceutical, biotechnology, or clinical research. • Proficiency in project management tools such as Jira, Azure DevOps, Smartsheet, MS Project, and ServiceNow • Strong experience with risk management, issue resolution, dependency tracking, and change management. • PMP, PgMP, SAFe, MSP, or similar certification preferred. • Knowledge of GxP or validated technology environments is a plus. • Bachelor's degree in Information Technology, Business, Engineering, Life Sciences, or a related field. Compensation for the Principal IT Project Manager includes: • Salary range: $130,000 - $170,000 base salary depending on experience • Comprehensive benefits package including medical, dental, vision, 401(k), PTO, and additional company-sponsored benefits This job opens for applications on 10/15/2026. Applications for this job will be accepted for at least 30 days from the posting date. Keywords: Principal IT Project Manager, IT Project Manager, Technical Project Manager, Senior Project Manager, Program Manager, Technology Program Management, Enterprise IT, Digital Transformation, Project Delivery, PMO, Portfolio Management, Agile, Scrum, Waterfall, Hybrid Methodology, SDLC, IT Governance, Stakeholder Management, Executive Communication, Risk Management, Change Management, Dependency Management, Resource Planning, Budget Management, Forecasting, Vendor Management, Jira, Azure DevOps, Smartsheet, Microsoft Project, ServiceNow, Technology Delivery, Enterprise Applications, Infrastructure Projects, Cloud Projects, Systems Implementation, Business Transformation, Life Sciences, Clinical Research, CRO, Healthcare IT, Pharmaceutical Technology #LI-BR1 #LI-REMOTE