Senior Research Associate, Cancer Immunology The Opportunity: As a key member of our Cancer Immunology team in this lab-based role, you will serve as the primary point of contact for flow cytometry operations – responsible for the following: • Managing flow cytometer instruments: • • Perform daily startup, quality control (QC), routine maintenance, and performance verification of flow cytometers and cell sorter. • Troubleshoot instrument issues and coordinate repairs and preventative maintenance with external vendors as needed. • Maintain inventories of instrument consumables and reagents. • Performing routine flow cytometry assays. • • Execute sample preparation and acquisition workflows, including sample handling, processing, and staining, in compliance with established SOPs. • Perform antibody titrations to optimize staining conditions for new and existing panels, and support spectral panel optimization, including fluorophore selection and spectral unmixing. • Perform data acquisition and analysis. • Optimize sample preparation, staining, and acquisition methods. • Providing technical support. • • Train new users on instrument startup, QC procedures, sample acquisition, and best laboratory practices. • Assist scientists with experimental design and flow cytometry workflows. • Develop and maintain standard operating procedures (SOPs) for instrument operation and flow cytometry assays. • Manage flow cytometer instrument data, including storage, backup, and export of flow cytometry files. • Monitor and evaluate emerging flow cytometry technologies, reagents, and workflows to maintain up-to-date knowledge of novel dyes, fluorochromes, instrumentation, and assay standards. • Manage flow cytometry core calendaring. Required Skills, Experience and Education: • Bachelor’s degree or Master’s degree in Science with 3+ years of experience in a cell biology/cellular assay development role. Title will be adjusted according to experience. • Deep expertise with multi-color spectral flow cytometry assays. • High proficiency in designing high-parameter flow panels and running experiments independently, including sample handling, cell staining, and data acquisition and analysis. • Highly organized and proactive, with a demonstrated ability to identify opportunities to improve laboratory workflows and operational efficiency. • Rigorous and quantitative approach, strong attention to detail, and excellent record-keeping skills. • Excellent written and verbal communication skills to facilitate collaboration with project and departmental teams. • Innovative, proactive team player who thrives in a fast-paced drug discovery and development environment. Preferred Skills: • Prior experience as a Flow Cytometry core manager. • Prior experience working with Cytek Aurora flow cytometer and SH800S sorter. • Hands-on experience with primary immune cells, including human PBMC handling, isolation and differentiation. • Immuno-oncology assays including immune cell phenotypic and functional characterization by flow cytometry (T cell proliferation, suppression and killing assays, antigen presentation assays, phagocytosis assays, etc.). • Prior experience utilizing electronic laboratory notebooks.