Position Summary We are seeking a highly motivated Senior Scientist with expertise in LC-MS-based antibody/protein characterization and/or bioanalytical quantitation to support oncology drug discovery. The successful candidate will perform hands-on analytical research focused on antibody-drug conjugates (ADCs), antibodies, and small molecules using LC-MS and HPLC technologies. This role partners closely with multidisciplinary teams to develop, optimize, and apply analytical methods that support discovery and early development programs. Key Responsibilities • Perform analytical characterization and quality control of ADCs, antibodies, and small molecules using LC-MS and HPLC techniques, including: Intact mass analysis, de-glycosylation and reducing LC-MS, Drug-to-antibody ratio (DAR) determination, HPLC methods such as size exclusion chromatography (SEC), hydrophobic interaction chromatography (HIC), and reverse-phase (RP), peptide mapping (a plus). • Prepare and analyze samples from purified proteins and biological matrices, including plasma, serum, and tissues. • Identify and characterize ADC metabolites from in vitro and in vivo studies using analytical techniques such as affinity capture, forced release, MS/MS, and SIM-MS. • Develop, optimize, validate, and troubleshoot analytical methods to improve performance and resolve technical challenges. • Operate, maintain, and troubleshoot analytical instrumentation, such as Thermo Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, Agilent HPLC, and UV-Vis systems. • Evaluate and recommend new analytical technologies and instrumentation to expand internal capabilities. • Document experimental work in electronic laboratory notebooks (ELNs), maintain analytical databases, and prepare technical reports and project summaries. • Present experimental results and scientific findings to multidisciplinary project teams. • Contribute to laboratory operations by maintaining shared equipment, supporting laboratory organization, and improving analytical workflows and efficiencies. Qualifications • Ph.D. or equivalent degree in Analytical chemistry or a related field with minimum 5 years’ experience, MS degree with 8 years’, or BS degree with 11 years’. • Industry experience in analytical chemistry within the biopharmaceutical or pharmaceutical industry. • Hands-on experience with protein and bioconjugate characterization using LC-MS, UV-Vis, and HPLC. • Experience with protein sample preparation techniques, including de-glycosylation, reduction, and enzymatic digestions of ADCs. • Working knowledge of chromatographic methods, including SEC, HIC, and reverse-phase HPLC. • Experience operating, maintaining, and troubleshooting LC-MS and HPLC instrumentation. • Strong analytical and problem-solving skills with excellent attention to detail. • Ability to manage multiple priorities and work independently in a fast-paced environment. • Excellent written and verbal communication skills, with the ability to present scientific data to multidisciplinary teams. • Demonstrated ability to collaborate effectively with cross-functional teams, including chemists, protein engineers, and biologists. • Scientific curiosity, a passion for innovation, and enthusiasm for evaluating and implementing emerging analytical technologies. • A publication record in peer-reviewed scientific journals is desirable.